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Jakub Fichna Selected Research

Abdominal Pain (Pain, Abdominal)

4/2020Cyclic derivatives of morphiceptin possess anti-transit effect in the gastrointestinal tract and alleviate abdominal pain in mice.
11/2019Corrigendum to "The novel peripherally active cannabinoid type 1 and serotonin type 3 receptor agonist AM9405 inhibits gastrointestinal motility and reduces abdominal pain in mouse models mimicking irritable bowel syndrome" [Eur. J. Pharmacol. (2018), 836 34-43].
11/2019Corrigendum to "Systemic administration of serotonin exacerbates abdominal pain and colitis via interaction with the endocannabinoid system" [Biochem. Pharmacol. 161 (2019) 37-51].
1/2019Systemic administration of serotonin exacerbates abdominal pain and colitis via interaction with the endocannabinoid system.
1/2019Alterations of colonic sensitivity and gastric dysmotility after acute cisplatin and granisetron.
10/2018The novel peripherally active cannabinoid type 1 and serotonin type 3 receptor agonist AM9405 inhibits gastrointestinal motility and reduces abdominal pain in mouse models mimicking irritable bowel syndrome.
7/2018Chronic abdominal pain in irritable bowel syndrome - current and future therapies.
1/2018Antinociceptive potency of enkephalins and enkephalinase inhibitors in the mouse model of colorectal distension-proof-of-concept.
4/2017Methyl-orvinol-Dual activity opioid receptor ligand inhibits gastrointestinal transit and alleviates abdominal pain in the mouse models mimicking diarrhea-predominant irritable bowel syndrome.
1/2016Novel investigational drugs for constipation-predominant irritable bowel syndrome: a review.
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Jakub Fichna Research Topics

Disease

43Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
02/2022 - 09/2013
40Inflammation (Inflammations)
01/2022 - 01/2014
35Colitis
02/2022 - 06/2012
25Irritable Bowel Syndrome (Syndrome, Irritable Bowel)
01/2022 - 08/2010
24Pain (Aches)
08/2021 - 02/2005
22Neoplasms (Cancer)
08/2022 - 12/2002
22Abdominal Pain (Pain, Abdominal)
04/2020 - 01/2012
21Crohn Disease (Crohn's Disease)
12/2021 - 06/2014
18Diarrhea
01/2022 - 07/2010
15Colorectal Neoplasms (Colorectal Cancer)
06/2021 - 09/2014
14Ulcerative Colitis
08/2021 - 07/2014
13Constipation
03/2022 - 01/2015
11Gastrointestinal Diseases (Functional Gastrointestinal Disorders)
03/2022 - 01/2012
10Visceral Pain
04/2020 - 01/2012
8Colonic Neoplasms (Colon Cancer)
02/2022 - 07/2014
6Carcinogenesis
08/2022 - 01/2016
5Ulcer
12/2020 - 01/2016
5Breast Neoplasms (Breast Cancer)
10/2009 - 08/2004
4Asthma (Bronchial Asthma)
02/2022 - 01/2016
4Body Weight (Weight, Body)
11/2021 - 10/2019
4Pancreatitis
10/2021 - 06/2019
3Obesity
01/2022 - 05/2018
3Colitis-Associated Neoplasms
01/2021 - 07/2014
3Multiple Sclerosis
01/2020 - 11/2012
2Idiopathic Pulmonary Fibrosis
02/2022 - 06/2021
2Fibrosis (Cirrhosis)
01/2022 - 08/2016
2Disease Progression
06/2021 - 01/2021
2Chronic Disease (Chronic Diseases)
03/2021 - 01/2020
2Nausea
01/2020 - 01/2019

Drug/Important Bio-Agent (IBA)

18Opioid Analgesics (Opioids)IBA
03/2022 - 08/2004
14Peroxidase (Myeloperoxidase)IBA
08/2021 - 06/2012
13Opioid Receptors (Opioid Receptor)IBA
03/2022 - 08/2004
11CytokinesIBA
03/2022 - 06/2014
9Dextran SulfateIBA
02/2022 - 01/2014
9Proteins (Proteins, Gene)FDA Link
06/2021 - 02/2005
8mu Opioid Receptors (mu Opioid Receptor)IBA
06/2017 - 08/2004
7morphiceptinIBA
10/2020 - 12/2002
6Analgesics (Analgesic Drugs)IBA
01/2021 - 01/2007
6Drinking WaterIBA
10/2020 - 10/2014
6CannabinoidsIBA
12/2019 - 01/2013
6Sulfonic AcidsIBA
01/2019 - 06/2012
5Castor Oil (Oil, Castor)IBA
01/2022 - 08/2014
5Fatty Acids (Saturated Fatty Acids)IBA
12/2021 - 01/2013
5AcidsIBA
12/2021 - 10/2015
5Nonesterified Fatty Acids (NEFA)IBA
11/2021 - 01/2020
5LigandsIBA
11/2021 - 08/2004
5Trinitrobenzenesulfonic AcidIBA
08/2021 - 10/2014
5Biomarkers (Surrogate Marker)IBA
06/2021 - 02/2016
5Dextrans (Dextran)FDA Link
03/2021 - 06/2012
5Peptides (Polypeptides)IBA
12/2020 - 01/2009
5SilverIBA
07/2020 - 01/2015
5Pharmaceutical PreparationsIBA
01/2020 - 01/2013
5EnzymesIBA
01/2018 - 11/2012
5Morphine (MS Contin)FDA LinkGeneric
01/2013 - 01/2007
4SolutionsIBA
05/2021 - 01/2012
4Neprilysin (Neutral Endopeptidase)IBA
12/2020 - 12/2016
4Estrogens (Estrogen)FDA Link
12/2020 - 01/2018
4sodium sulfate (sodium bisulfate)FDA LinkGeneric
10/2020 - 06/2012
4CB1 Cannabinoid Receptor (CB1 Receptor)IBA
12/2019 - 12/2014
4Serotonin (5 Hydroxytryptamine)IBA
11/2019 - 10/2018
4EndocannabinoidsIBA
11/2019 - 01/2013
4BerberineIBA
10/2019 - 01/2014
3G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA
08/2022 - 03/2017
3Glucose (Dextrose)FDA LinkGeneric
01/2022 - 08/2016
3Hormones (Hormone)IBA
12/2021 - 09/2013
3Naloxone (Narcan)FDA LinkGeneric
11/2021 - 02/2014
3LipidsIBA
11/2021 - 01/2016
3Messenger RNA (mRNA)IBA
06/2021 - 10/2009
3Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2021 - 06/2014
3Interleukin-6 (Interleukin 6)IBA
01/2021 - 12/2016
3Estrogen ReceptorsIBA
12/2020 - 01/2019
3GTP-Binding Proteins (G-Protein)IBA
06/2019 - 03/2015
3EnkephalinsIBA
02/2019 - 10/2014
3MelatoninIBA
01/2018 - 02/2014
3PolyphenolsIBA
01/2017 - 06/2015
3N- (2- (5- methoxy- indol- 3- yl)- ethyl)- 4- oxo- 4H- pyran- 2- carboxamideIBA
05/2016 - 02/2014
3Melatonin Receptors (Melatonin Receptor)IBA
05/2016 - 02/2014
3Narcotic Antagonists (Opioid Antagonists)IBA
02/2016 - 01/2009
3Opiate AlkaloidsIBA
06/2010 - 01/2007
2Tight Junction ProteinsIBA
03/2022 - 01/2017
2ChitinasesIBA
02/2022 - 06/2021
2GoldIBA
01/2022 - 03/2021
2Cisplatin (Platino)FDA LinkGeneric
01/2022 - 01/2019
2Insulin (Novolin)FDA Link
01/2022 - 05/2018
2Dipeptidyl Peptidase 4 (Dipeptidyl Peptidase IV)IBA
12/2021 - 10/2017
2Glucagon-Like Peptides (Enteroglucagon)IBA
12/2021 - 11/2019
2Blood Glucose (Blood Sugar)IBA
12/2021 - 11/2019
2Indicators and Reagents (Reagents)IBA
10/2021 - 10/2019
2Arginine (L-Arginine)FDA Link
10/2021 - 10/2019
2Chlorogenic AcidIBA
10/2021 - 06/2015
2C-Reactive ProteinIBA
08/2021 - 03/2021
2SodiumIBA
03/2021 - 01/2017
2Peptide Hydrolases (Proteases)FDA Link
01/2021 - 10/2017
2MicroRNAs (MicroRNA)IBA
01/2021 - 12/2018
2sialorphinIBA
12/2020 - 01/2018
2Loperamide (Imodium)FDA LinkGeneric
09/2020 - 01/2020

Therapy/Procedure

36Therapeutics
02/2022 - 02/2010
4Drug Therapy (Chemotherapy)
01/2019 - 06/2015
3Biological Therapy
01/2020 - 06/2014
2Oral Administration
05/2021 - 03/2014